Mechanistic interrogation of mitochondrial quality control pathways
We employ genetic and biochemical tools to uncover novel roles for mitochondrial proteins and their involvement in human health and disease.
We have identified proteases that are key regulators of mitophagy, and have linked them to the etiology of Parkinson’s disease.
Our Research
Small molecule drug discovery
We use human cell-based assays and Drosophila models of disease to screen, discover, validate and understand how mitophagy activators work and evaluate their therapeutic potential.